| Chemical Properties | Back Directory | [Boiling point ]
859.5±75.0 °C(predicted) | [density ]
1.628±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.43±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM[1]. | [IC 50]
PARP1: 4.62 nM (IC50) | [References]
[1] Xiaoyu Peng, et al. High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders. Eur J Med Chem. 2024 May 5:271:116405. DOI:10.1016/j.ejmech.2024.116405 |
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