| Identification | Back Directory | [Name]
2-Hydroxy Atorvastatin Lactone-d5 | [CAS]
265989-50-2 | [Synonyms]
2-Hydroxy Atorvastatin Lactone-d5
[2H5]-2-Hydroxy Atorvastatin Lactone
5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide
5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide-d5
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]- (9CI) | [Molecular Formula]
C33H33FN2O5 | [MDL Number]
MFCD08063402 | [MOL File]
265989-50-2.mol | [Molecular Weight]
556.624 |
| Chemical Properties | Back Directory | [Melting point ]
103-107°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
An isotopically labelled metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790. DOI:10.3109/00498254.2012.661100
[3] Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. DOI:10.1097/FJC.0b013e318123767f |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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