| Identification | Back Directory | [Name]
4H-Pyrido[1,2-a]pyrimidin-4-one, 7-(1-cyclopropyl-1H-pyrazol-4-yl)-2-[[2-fluoro-4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]amino]-3-methyl- | [CAS]
2662454-54-6 | [Synonyms]
NVS-BPTF-1
4H-Pyrido[1,2-a]pyrimidin-4-one, 7-(1-cyclopropyl-1H-pyrazol-4-yl)-2-[[2-fluoro-4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]amino]-3-methyl- | [Molecular Formula]
C26H28FN7O3S | [MOL File]
2662454-54-6.mol | [Molecular Weight]
537.61 |
| Chemical Properties | Back Directory | [Boiling point ]
699.7±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml | [pka]
5.87±0.42(Predicted) |
| Hazard Information | Back Directory | [Uses]
NVS-BPTF-1 is a selective inhibitor for bromodomain and PHD finger containing transcription factor (BPTF), with KD of 71 nM[1]. | [References]
[1] Mélin L, et al., Synthesis of NVS-BPTF-1 and evaluation of its biological activity. Bioorg Med Chem Lett. 2021 Sep 1;47:128208. DOI:10.1016/j.bmcl.2021.128208 |
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