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2663844-45-7

2663844-45-7 Structure

2663844-45-7 Structure
IdentificationBack Directory
[Name]

Nisotirostide
[CAS]

2663844-45-7
[Synonyms]

LY-3457263
Nisotirostide
Chemical PropertiesBack Directory
[solubility ]

DMSO: Soluble: = 10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
[form ]

Solid
[color ]

White to off-white
[Sequence]

Chain1:Pro-Lys-Pro-Glu-Lys-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Trp-Gln-Arg-Tyr-Tyr-Ala-Glu-Leu-Arg-His-Tyr-Leu-Asn-Trp-Leu-Thr-Arg-Gln-Arg-Tyr-NH2; Chain2:Ggu-Ggu-Oaa (Amide bridge:Chain1 Lys5-Chain2 Oaa3)
Hazard InformationBack Directory
[Uses]

Nisotirotide (LY-3457263) is a PYY analog agonist studied in type 2 diabetes and obesity[1].
[References]

[1] Kloock S, et al. Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery? Pharmacol Ther. 2023 Nov;251:108549. DOI:10.1016/j.pharmthera.2023.108549
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