| Identification | Back Directory | [Name]
Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- | [CAS]
2667681-57-2 | [Synonyms]
IRAK4-IN-13
Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- | [Molecular Formula]
C24H27N9O | [MOL File]
2667681-57-2.mol | [Molecular Weight]
457.53 |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 μL/min/mg[1]. | [IC 50]
IRAK4: 0.6 nM (IC50) | [References]
[1] Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815. DOI:10.1016/j.bmc.2020.115815 |
|
|