| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2669785-84-4 | [Synonyms]
JPS035
(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide | [Molecular Formula]
C49H65N7O7S | [MOL File]
2669785-84-4.mol | [Molecular Weight]
896.16 |
| Hazard Information | Back Directory | [Uses]
JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. | [References]
[1] Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659. DOI:10.1021/acs.jmedchem.1c02179 |
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