| Identification | Back Directory | [Name]
3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide | [CAS]
26723-60-4 | [Synonyms]
3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol
3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-...
3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-ol
3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide
3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE
Dibenzo[c,f][1,2]thiazepin-11-ol, 3-chloro-6,11-dihydro-6-methyl-, 5,5-dioxide
3-Chloro-6,11-dihydro-6-methyl-11-hydroxydibenzo[c,f][1,2]thiazepine 5,5-dioxide
3-Chloro-11-hydroxy-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide | [EINECS(EC#)]
247-944-1 | [Molecular Formula]
C14H12ClNO3S | [MDL Number]
MFCD07368144 | [MOL File]
26723-60-4.mol | [Molecular Weight]
309.77 |
| Chemical Properties | Back Directory | [Melting point ]
196-198°C | [Boiling point ]
482.8±55.0 °C(Predicted) | [density ]
1.472±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.60±0.20(Predicted) | [color ]
White | [Water Solubility ]
30mg/L at 25℃ | [LogP]
2.78 |
| Hazard Information | Back Directory | [Uses]
3-Chloro-6,11-dihydro-5,5-dioxo-11-hydroxy-6-methyldibenzo[c,f][1,2]thiazepine, can beused in the synthesis of Dibenzo[c,f][1,2]thiazepine derivatives. | [Synthesis]
The general procedure for the synthesis of 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide from 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide was as follows: to a solution of 3-chloro-6-methyl-dibenzo[c,f][1,2]thiazepin- 11(6H)-one 5,5-dioxide (62.5 g) to a solution of methanol (500 ml), sodium borohydride (15.04 g) was slowly added at 0-5 °C. The reaction mixture was stirred at 0-5 °C for 30 min, followed by continued stirring at room temperature for 30-60 min. After completion of the reaction, the solid product was collected by filtration and washed with methanol. The resulting solid was dried under constant weight to afford 3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide in 90-95% yield. | [References]
[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496 |
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