| Identification | Back Directory | [Name]
Phenol, 4-[3-[4-(1-piperazinyl)phenyl]-1H-indazol-6-yl]- | [CAS]
2677709-81-6 | [Synonyms]
Phenol, 4-[3-[4-(1-piperazinyl)phenyl]-1H-indazol-6-yl]- | [Molecular Formula]
C23H22N4O | [MOL File]
2677709-81-6.mol | [Molecular Weight]
370.45 |
| Chemical Properties | Back Directory | [Boiling point ]
674.3±55.0 °C(Predicted) | [density ]
1.266±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 62.5 mg/mL (168.71 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
9.70±0.15(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Biological Activity]
FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1]. | [References]
[1]. Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65(2):1481-1504. |
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