Identification | Back Directory | [Name]
2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- | [CAS]
2677786-27-3 | [Synonyms]
GRK6-IN-2 2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]- | [Molecular Formula]
C21H21FN6 | [MOL File]
2677786-27-3.mol | [Molecular Weight]
376.43 |
Chemical Properties | Back Directory | [Boiling point ]
612.5±65.0 °C(Predicted) | [density ]
1.334±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.27±0.10(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1]. | [References]
[1] Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. DOI:10.1021/acs.jmedchem.1c00506 |
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