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2677786-27-3

2677786-27-3 Structure

2677786-27-3 Structure
IdentificationBack Directory
[Name]

2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-
[CAS]

2677786-27-3
[Synonyms]

GRK6-IN-2
2,4-Quinazolinediamine, N4-(5-ethyl-1H-pyrazol-3-yl)-N2-[(1S)-1-(4-fluorophenyl)ethyl]-
[Molecular Formula]

C21H21FN6
[MOL File]

2677786-27-3.mol
[Molecular Weight]

376.43
Chemical PropertiesBack Directory
[Boiling point ]

612.5±65.0 °C(Predicted)
[density ]

1.334±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

14.27±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].
[References]

[1] Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. DOI:10.1021/acs.jmedchem.1c00506
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