| Identification | Back Directory | [Name]
Benzonitrile, 4-[[4-[[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]methyl]-1-piperazinyl]methyl]- | [CAS]
2684291-60-7 | [Synonyms]
Antioxidant agent-5
Benzonitrile, 4-[[4-[[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]methyl]-1-piperazinyl]methyl]- | [Molecular Formula]
C24H24N6O | [MOL File]
2684291-60-7.mol | [Molecular Weight]
412.49 |
| Hazard Information | Back Directory | [Uses]
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1]. | [References]
[1] Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606. DOI:10.1016/j.bioorg.2022.105606 |
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