| Identification | Back Directory | [Name]
Benzonitrile, 4-[2-(2,4-dimethoxyphenyl)-4-thiazolyl]- | [CAS]
2685779-55-7 | [Synonyms]
CYP1B1-IN-4
Benzonitrile, 4-[2-(2,4-dimethoxyphenyl)-4-thiazolyl]- | [Molecular Formula]
C18H14N2O2S | [MOL File]
2685779-55-7.mol | [Molecular Weight]
322.38 |
| Chemical Properties | Back Directory | [Boiling point ]
544.5±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.87±0.50(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1]. | [IC 50]
CYP1B1: 0.2 nM (IC50); CYP1A1: 3.98 μM (IC50) | [References]
[1] Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15. DOI:10.1021/acs.jmedchem.2c01368 |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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