| Identification | Back Directory | [Name]
FENOPROFEN SODIUM SALT HYDRATE (RING-13C6, 99%) | [CAS]
2687960-29-6 | [Synonyms]
FENOPROFEN SODIUM SALT HYDRATE (RING-13C6, 99%) | [Molecular Formula]
C6C7H13O3 |
| Hazard Information | Back Directory | [Description]
Fenoprofen-13C6 is intended for use as an internal standard for the quantification of fenoprofen (Item No. 23835) by GC- or LC-MS. Fenoprofen is a non-steroidal anti-inflammatory drug (NSAID).1 It inhibits spontaneous and estradiol-stimulated prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020) release by 84% in isolated rat uterine horns when used at a concentration of 33 μM. Fenoprofen (10 mg/kg, i.p.) reduces serum PGF2α levels in rats. It reduces acetic acid-induced writhing and stretching and formalin-induced licking behaviors in mice, however, it also induces the formation of gastric lesions in mice.2 Formulations containing fenoprofen have been used in the treatment of pain and the signs and symptoms of rheumatoid arthritis and osteoarthritis.WARNING This product is not for human or veterinary use. | [References]
[1] C. PATRONO D. G B G Ciabattoni. In vitro and in vivo inhibition of prostaglandin synthesis by fenoprofen, a non steroid anti-inflammatory drug[J]. Pharmacological research communications, 1974, 6 5: Pages 509-518. DOI: 10.1016/s0031-6989(74)80060-3
[2] MARIELA AGOTEGARAY. Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases.[J]. BioMed Research International, 2014: 505987. DOI: 10.1155/2014/505987 |
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