| Identification | Back Directory | [Name]
4,7,10,13,16,19-Docosahexaenoic-21,21,22,22,22-d5 acid, methyl ester, (4Z,7Z,10Z,13Z,16Z,19Z)- | [CAS]
2687960-96-7 | [Synonyms]
Docosahexaenoic acid methyl ester-D5
4,7,10,13,16,19-Docosahexaenoic-21,21,22,22,22-d5 acid, methyl ester, (4Z,7Z,10Z,13Z,16Z,19Z)- | [Molecular Formula]
C23H34O2 | [MOL File]
2687960-96-7.mol | [Molecular Weight]
342.52 |
| Hazard Information | Back Directory | [Uses]
Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. DOI:10.1016/j.brainres.2013.09.004
[3] Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66. DOI:10.1016/j.bbapap.2006.11.014 |
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