ChemicalBook--->CAS DataBase List--->2688842-08-0

2688842-08-0

2688842-08-0 Structure

2688842-08-0 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2688842-08-0
[Synonyms]

Histone Methyltransferase,PROTACs,inhibit,Inhibitor,UNC6852,EED,UNC 6852,PRC2,PROTAC,UNC-6852
(2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
[Molecular Formula]

C43H48N10O6S
[MOL File]

2688842-08-0.mol
[Molecular Weight]

832.98
Chemical PropertiesBack Directory
[density ]

1.40±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear (Warmed)
[form ]

Solid
[pka]

13.49±0.46(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) th at targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development)EZH2 (enhancer of zeste homolog 2)and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.
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