| Identification | Back Directory | [Name]
1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- | [CAS]
2697176-16-0 | [Synonyms]
1H-Indole-2-carboxamide, 4-fluoro-7-methyl-N-[(1R,3S)-3-[(3S)-3-[methyl(methylsulfonyl)amino]-1-pyrrolidinyl]cyclohexyl]- | [Molecular Formula]
C22H31FN4O3S | [MOL File]
2697176-16-0.mol | [Molecular Weight]
450.57 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
14.79±0.40(Predicted) | [color ]
Off-white to yellow | [SMILES]
FC1=C2C(NC(C(N[C@H]3C[C@@H](N4C[C@H](CC4)N(C)S(C)(=O)=O)CCC3)=O)=C2)=C(C=C1)C.[0.75H2O] |
| Hazard Information | Back Directory | [Biological Activity]
EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases. | [References]
[1]. Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12(10):1539-1545. |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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