| Identification | Back Directory | [Name]
Benzonitrile, 3-[4-amino-5-fluoro-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-2-pyrimidinyl]-2-methyl- | [CAS]
2703054-47-9 | [Synonyms]
Adenosine receptor antagonist 2
Benzonitrile, 3-[4-amino-5-fluoro-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-2-pyrimidinyl]-2-methyl- | [Molecular Formula]
C23H21FN8O | [MOL File]
2703054-47-9.mol | [Molecular Weight]
444.46 |
| Chemical Properties | Back Directory | [Boiling point ]
614.3±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
13.32±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1]. Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1].
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min.kg and an AUC of 2252 h.ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].
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