| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 5-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [CAS]
2703775-06-6 | [Synonyms]
1H-Isoindole-1,3(2H)-dione, 5-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | [Molecular Formula]
C23H32ClN3O9 | [MOL File]
2703775-06-6.mol | [Molecular Weight]
529.97 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1005. DOI:10.1016/S1473-3099(20)30650-2 |
|
|