| Identification | Back Directory | [Name]
3-Pyrrolidinecarboxamide, N-[5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]-1-cyano-, (3S)- | [CAS]
2705841-52-5 | [Synonyms]
8RK64
3-Pyrrolidinecarboxamide, N-[5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]-1-cyano-, (3S)- | [Molecular Formula]
C14H16N8O2S | [MOL File]
2705841-52-5.mol | [Molecular Weight]
360.4 |
| Hazard Information | Back Directory | [Uses]
8RK64 is a covalent UCHL1 inhibitor (IC50: 0.32 μM)[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
8RK64 is a cell penetrantpotent and selective covalent inhibitor of UCHL1 (ubiquitin carboxy-terminal hydrolase L1) th at binds to the active-site cysteine residue of UCHL1. 8RK64 potently inhibits UCHL1 activity in cells. | [References]
[1] Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. DOI:10.1021/jacs.0c07726 |
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Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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