| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 5-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-, ethyl ester | [CAS]
2705900-81-6 | [Synonyms]
ALK5-IN-8
Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 5-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-, ethyl ester | [Molecular Formula]
C19H15FN4O2 | [MOL File]
2705900-81-6.mol | [Molecular Weight]
350.35 |
| Hazard Information | Back Directory | [Uses]
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1]. | [References]
[1] Zhiyong Yu, et al. Transforming growth factor-beta receptor inhibitor. Patent WO2021190425A1. |
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