| Identification | Back Directory | [Name]
Benzoic acid, 5-[[(7,8-dihydroxy-6-nitro-2-oxo-2H-1-benzopyran-3-yl)carbonyl]amino]-2-hydroxy-, methyl ester | [CAS]
2709085-95-8 | [Synonyms]
HIV-1 integrase inhibitor 9
Benzoic acid, 5-[[(7,8-dihydroxy-6-nitro-2-oxo-2H-1-benzopyran-3-yl)carbonyl]amino]-2-hydroxy-, methyl ester | [Molecular Formula]
C18H12N2O10 | [MOL File]
2709085-95-8.mol | [Molecular Weight]
416.3 |
| Hazard Information | Back Directory | [Uses]
HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC50 of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity[1]. | [IC 50]
HIV-1 RNase H: 12.3 nM (IC50) | [References]
[1] Dongwei Kang, et al. Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors. Eur J Med Chem. 2021 Dec 5;225:113769. DOI:10.1016/j.ejmech.2021.113769 |
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