| Hazard Information | Back Directory | [Description]
Cystamine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cystamine by GC- or LC-MS. Cystamine is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM.1 It is orally available and is neuroprotective in mouse models of Huntington’s disease.2,3 Cystamine also inhibits caspase-3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.4 | [Uses]
Cystamine-d8 (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4]. | [References]
1. Smethurst, P.A., and Griffin, M. Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotides Biochem. J. 313(pt 3),803-808(1996).
2. Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al. Therapeutic effects of cystamine in a murine model of Huntington’s disease J. Neurosci. 22(20),8942-8950(2002).
3. Borrell-Pagès, M., Canals, K.P., Cordelièrs, F.P., et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase J. Clin. Invest. 116(5),1410-1424(2006).
4. Elli, L., Ciulla, M.M., Busca, G., et al. Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease Lab. Invest. 91(3),452-461(2011). |
|
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|