| Identification | Back Directory | [Name]
MMK 1 | [CAS]
271246-66-3 | [Synonyms]
MMK 1
L-Methionine, L-leucyl-L-α-glutamyl-L-seryl-L-isoleucyl-L-phenylalanyl-L-arginyl-L-seryl-L-leucyl-L-leucyl-L-phenylalanyl-L-arginyl-L-valyl- | [Molecular Formula]
C75H123N19O18S | [MDL Number]
MFCD11113650 | [MOL File]
271246-66-3.mol | [Molecular Weight]
1610.96 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 0.50 mg/ml in 25% ethanol / water with sonication | [form ]
film or powder | [color ]
white to beige | [Water Solubility ]
Soluble to 1 mg/ml in 25% ethanol / Water | [Sequence]
H-Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met-OH | [InChIKey]
PWBQRCXCXXGUGY-AJOXZCOLSA-N |
| Hazard Information | Back Directory | [Uses]
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4]. | [Biological Activity]
MMK-1 is a potent and selective FPR2 (FPRL-1) agonist (Ca2+ flux EC50 <2 nM/FPR2 vs. >10 μM/FPR1 with respective HEK293 transfectants) and an effective calcium-mobilizing and chemotactic agent for human monocytes & neutrophils (1-1000 nM). MMK-1 increases pertussis toxin-sensitive inflammatory cytokines production in human monocyte cultures (50 ng/mL PT & 10 μM MMK-1)exerts anxiolytic-like activities in mice (100 pmol/mouse icv) and shows anti-alopecia efficacy in rats in vivo (100 mg/kg p.o. or 10 mg/kg i.p.). | [in vivo]
MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4].
| Animal Model: | Four-week-old male ddY mice[4] | | Dosage: | 10, 100, 1000 pmol/mouse | | Administration: | ICV; 20 min before the test | | Result: | Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse. |
| [IC 50]
Calcium Channel | [storage]
Store at -20°C | [References]
[1] C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. DOI:10.1038/4310
[2] Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. DOI:10.3390/cells10081975
[3] Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. DOI:10.1038/s41598-018-32963-5
[4] Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. DOI:10.1016/j.peptides.2016.07.001 |
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