| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole-3-carboxamide, 1-(3,4-dichlorophenyl)-8-methyl-N-[2-(methylamino)ethyl]-, hydrochloride (1:1) | [CAS]
2715222-97-0 | [Synonyms]
Antimalarial agent 8
9H-Pyrido[3,4-b]indole-3-carboxamide, 1-(3,4-dichlorophenyl)-8-methyl-N-[2-(methylamino)ethyl]-, hydrochloride (1:1) | [Molecular Formula]
C22H21Cl3N4O | [MOL File]
2715222-97-0.mol | [Molecular Weight]
463.79 |
| Hazard Information | Back Directory | [Uses]
Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria[1]. | [IC 50]
Plasmodium | [References]
[1] Mathew J, et al. Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials. ACS Med Chem Lett. 2022;13(3):365-370. DOI:10.1021/acsmedchemlett.1c00663 |
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