| Identification | Back Directory | [Name]
(2,4-Dichlorophenyl)[(2S)-2-phenyl-4-morpholinyl]methanone | [CAS]
2716077-17-5 | [Synonyms]
F0045(S)
(2,4-Dichlorophenyl)[(2S)-2-phenyl-4-morpholinyl]methanone | [Molecular Formula]
C17H15Cl2NO2 | [MOL File]
2716077-17-5.mol | [Molecular Weight]
336.21 |
| Chemical Properties | Back Directory | [Boiling point ]
513.2±50.0 °C(Predicted) | [density ]
1.325±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
-2.47±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
F0045(S) is a potent influenza hemagglutinin inhibitor with a KD value of 6.1 μM. F0045(S) protects human cells from influenza infection[1][2]. | [References]
[1] Kitamura S, et al. Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2310677121. DOI:10.1073/pnas.2310677121
[2] Yao Y, et al. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438. DOI:10.1073/pnas.2006893117 |
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