| Identification | Back Directory | [Name]
Phosphonium, triphenyl[6-(6-phenylimidazo[2,1-b]-1,3,4-thiadiazol-2-yl)hexyl]-, bromide (1:1) | [CAS]
2716909-84-9 | [Synonyms]
Phosphonium, triphenyl[6-(6-phenylimidazo[2,1-b]-1,3,4-thiadiazol-2-yl)hexyl]-, bromide (1:1) | [Molecular Formula]
C34H33N3PS.Br | [MOL File]
2716909-84-9.mol | [Molecular Weight]
626.59 |
| Hazard Information | Back Directory | [Uses]
AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM). HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research[1][2]. | [IC 50]
HSP70: 180 nM (IC50) | [References]
[1] Barnoud T, et al. A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors[J]. Cancer research, 2020, 80(23): 5270-5281. DOI:10.1158/0008-5472.CAN-20-0397
[2] Ferretti G D S, et al. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer[J]. Cell Death & Differentiation, 2024: 1-16. DOI:10.1038/s41418-024-01310-9 |
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