| Identification | Back Directory | [Name]
6-[(1,1-Dimethylethyl)sulfonyl]-7-methoxy-N-(4-methyl-1H-pyrazol-3-yl)-4-quinolinamine | [CAS]
2724942-14-5 | [Synonyms]
6-[(1,1-Dimethylethyl)sulfonyl]-7-methoxy-N-(4-methyl-1H-pyrazol-3-yl)-4-quinolinamine | [Molecular Formula]
C18H22N4O3S | [MOL File]
2724942-14-5.mol | [Molecular Weight]
374.46 |
| Chemical Properties | Back Directory | [Boiling point ]
633.0±55.0 °C(Predicted) | [density ]
1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
14.39±0.50(Predicted) | [color ]
white to beige | [InChI]
1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22) | [InChIKey]
WCPMUQAUSFXFJE-UHFFFAOYSA-N | [SMILES]
CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32 |
| Hazard Information | Back Directory | [Biological Activity]
AS3334034 is an orally availablepotent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor th at exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears th at AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|