| Identification | Back Directory | [Name]
Boronic acid, B-[(1R)-3-methyl-1-[[(2R)-1-oxo-2-[(2-pyrazinylcarbonyl)amino]hexyl]amino]butyl]- | [CAS]
2729981-17-1 | [Synonyms]
LONP1-IN-2
Boronic acid, B-[(1R)-3-methyl-1-[[(2R)-1-oxo-2-[(2-pyrazinylcarbonyl)amino]hexyl]amino]butyl]- | [Molecular Formula]
C16H27BN4O4 | [MOL File]
2729981-17-1.mol | [Molecular Weight]
350.22 |
| Hazard Information | Back Directory | [Uses]
LONP1-IN-2 (compound 9e) is a potent and selective LONP1 inhibitor with IC50 values of 0.093 μM and >10 μM for LONP1 and 20S proteasome, respectively. LONP1-IN-2 can be used in research of cancer[1]. | [References]
[1] Kingsley LJ, et, al. Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J Med Chem. 2021 Apr 22;64(8):4857-4869. DOI:10.1021/acs.jmedchem.0c02152 |
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