| Identification | Back Directory | [Name]
3-[[2-[4-(1,1-Dioxido-4-thiomorpholinyl)phenyl]-4-pyrimidinyl]oxy]-2,6-difluorophenol | [CAS]
2730027-86-6 | [Synonyms]
3-[[2-[4-(1,1-Dioxido-4-thiomorpholinyl)phenyl]-4-pyrimidinyl]oxy]-2,6-difluorophenol | [Molecular Formula]
C20H17F2N3O4S | [MOL File]
2730027-86-6.mol | [Molecular Weight]
433.43 |
| Chemical Properties | Back Directory | [Boiling point ]
559.7±50.0 °C(Predicted) | [density ]
1.457±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
6.37±0.15(Predicted) |
| Hazard Information | Back Directory | [Uses]
HSD17B13-IN-36 (compound 116) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM? estradiol? as substrates. HSD17B13-IN-36? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1]. | [References]
[1] Inipharm, Inc. Preparation of substituted phenoxypyridines and phenoxypyrimidines as HSD17B13 inhibitors and uses thereof. World Intellectual Property Organization, WO2021211974 A1 2021-10-21 |
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