| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
A novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. This is the labeled analog. | [References]
[1] DIANE H. BOSCHELLI. Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity[J]. Journal of Medicinal Chemistry, 2001, 44 23: 3965-3977. DOI: 10.1021/jm0102250
[2] JENNIFER M GOLAS. SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.[J]. Cancer research, 2003, 63 2: 375-381.
[3] L L REMSING RIX. Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells[J]. Leukemia, 2008, 23 3: 477-485. DOI: 10.1038/leu.2008.334 |
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