| Chemical Properties | Back Directory | [Boiling point ]
711.5±70.0 °C(Predicted) | [density ]
2.12±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.96±0.70(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 5 mg/mL (16.46 mM; ultrasonic and warming and heat to 60°C) |
| Hazard Information | Back Directory | [Uses]
Fludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases[1]. | [Biological Activity]
Fludarabine-Cl has inhibition effect on RNA adenosine deaminase 1(ADAR1), and can be used for preventing and/or treating cancer or tumor-related diseases[1]. | [in vivo]
Fludarabine-Cl (104.9-400 mg/kg, intraperitoneal injection, twice a day, for one day) has some toxicity in mice, with an LD50 of 186.5641 mg/kg[1].
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1]. | Animal Model: | ICR mice[1] | | Dosage: | 104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs. |
| Animal Model: | BALB/c mice induced by Du-145[1] | | Dosage: | 10, 20 mg/kg; twice a day; 29 days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Inhibited tumor growth and had no effect on mouse body weight. |
| [IC 50]
ADAR1: 0.87 μM (IC50) | [References]
[1]. Polysubstituted purine compound and preparation method and application thereof. CN113549076A. |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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