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JAK1/TYK2-IN-4 is a dual inhibitor of JAK and TYK2, with IC50s of 39 nM and 21 nM, respectively. JAK1/TYK2-IN-4 has oral bioavailability[1]. | [References]
[1] Xue Cui, et al. Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease. Int Immunopharmacol. 2023 Nov 20:126:111238. DOI:10.1016/j.intimp.2023.111238 |
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