| Identification | Back Directory | [Name]
1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3R)- | [CAS]
2735015-59-3 | [Synonyms]
(R)-TTBK1-IN-1
1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3R)- | [Molecular Formula]
C18H19N5O2 | [MOL File]
2735015-59-3.mol | [Molecular Weight]
337.38 |
| Chemical Properties | Back Directory | [Boiling point ]
557.8±60.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.91±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1]. (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380. DOI:10.1021/acs.jmedchem.1c00382 |
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