| Identification | Back Directory | [Name]
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- | [CAS]
273727-89-2 | [Synonyms]
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- | [Molecular Formula]
C23H25NO | [MDL Number]
MFCD11045596 | [MOL File]
273727-89-2.mol | [Molecular Weight]
331.45 |
| Chemical Properties | Back Directory | [Boiling point ]
478.8±28.0 °C(Predicted) | [density ]
1.083±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.99±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. | [Definition]
ChEBI: 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone is a member of naphthalenes. | [IC 50]
JAK3: 7.1 (pIC50); JAK1: 4.4 (pIC50); EGF-R: 5.6 (pIC50); Lck: 5.0 (pIC50); CDK4: 5.0 (pIC50); TGM2: 10 nM (IC50) | [References]
[1] Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DOI:10.1016/s0960-894x(00)00051-2
[2] Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. DOI:10.1016/j.chembiol.2008.07.015
[3] Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197. DOI:10.3892/ol.2017.5861 |
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