| Identification | Back Directory | [Name]
ACEA | [CAS]
273734-07-9 | [Synonyms]
ACEA
2'-CHLORO-AEA
ARACHIDONYL-2-CHLOROETHYLAMIDE
ARACHIDONYL-2'-CHLOROETHYLAMIDE
ARACHIDONOYL 2'-CHLOROETHYLAMIDE
N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
Propanamide, 3-chloro-N-(4Z,7Z,10Z,13Z)-4,7,10,13-nonadecatetraen-1-yl- | [Molecular Formula]
C22H36ClNO | [MDL Number]
MFCD02683581 | [MOL File]
273734-07-9.mol | [Molecular Weight]
365.98 |
| Hazard Information | Back Directory | [Definition]
ChEBI:Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid. | [Enzyme inhibitor]
This synthetic CB1 receptor agonist and anandamide (N-
arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-
4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki =
1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM).
ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster
ovary cells expressing the human CB1 receptor. It also increases the
binding of [35S]GTPgS to cerebellar membranes and inhibits electrically
evoked contractions of the mouse vas deferens. ACEA produces
hypothermia in mice, an effect that is inhibited by co-administration of the
CB1 receptor antagonist SR141716A. |
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