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Almorexant-13C-d3 is a labelled isotope of of Almorexant (A575195) . Almorexant regulates sleep and wakefulness through two G protein-coupled receptors. | [References]
[1] PARI MALHERBE. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists.[J]. Molecular Pharmacology, 2009, 76 3: 618-631. DOI: 10.1124/mol.109.055152
[2] CATHERINE BRISBARE-ROCH. Promotion of sleep by targeting the orexin system in rats, dogs and humans[J]. Nature Medicine, 2007, 13 2: 150-155. DOI: 10.1038/nm1544
[3] HENDRIK DIETRICH François J. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.[J]. Psychopharmacology, 2010, 212 2: 145-154. DOI: 10.1007/s00213-010-1933-5 |
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