| Chemical Properties | Back Directory | [Boiling point ]
399.5±42.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [solubility ]
DMF: 11 mg/ml
DMF: PBS (pH 7.2) (1:2): 0.3 mg/ml
DMSO: 10 mg/ml | [pka]
13.04±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antiviral agent 43 (compound 16) is a potent and orally active influenza A viruses entry inhibitor. Antiviral agent 43 inhibits replications of influenza A strains VH04-H5N1 and PR8-H1N1 with EC50s of 240 nM and 72 nM, respectively[1]. | [References]
[1] Irina N Gaisina, et al. Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir. J Med Chem. 2020 Mar 26;63(6):3120-3130. DOI:10.1021/acs.jmedchem.9b01900 |
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