| Identification | Back Directory | [Name]
1H-Indole-6-carboximidamide, 2-[4-[[4-(aminoiminomethyl)phenyl]amino]phenyl]-, hydrochloride (1:1) | [CAS]
2741856-68-6 | [Synonyms]
1H-Indole-6-carboximidamide, 2-[4-[[4-(aminoiminomethyl)phenyl]amino]phenyl]-, hydrochloride (1:1) | [Molecular Formula]
C22H21ClN6 | [MOL File]
2741856-68-6.mol | [Molecular Weight]
404.9 |
| Hazard Information | Back Directory | [Uses]
Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the?SNCA?mRNA?that encodes α-synuclein protein. Synucleozid selectively?targets the?α-synuclein?mRNA 5′ UTR at the designed IRE site, decreases the amount of?SNCA?mRNA loaded into polysomes and thereby inhibits?SNCA?translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1]. | [References]
[1] Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467. DOI:10.1073/pnas.1905057117 |
|
|