| Identification | Back Directory | [Name]
Cyclohexanol, 2-[(4-fluorophenyl)amino]-1-(trifluoromethyl)-, (1R,2R)- | [CAS]
2741956-55-6 | [Synonyms]
BAY-390
Cyclohexanol, 2-[(4-fluorophenyl)amino]-1-(trifluoromethyl)-, (1R,2R)- | [Molecular Formula]
C13H15F4NO | [MOL File]
2741956-55-6.mol | [Molecular Weight]
277.26 |
| Chemical Properties | Back Directory | [Boiling point ]
337.2±42.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Ethanol: Slightly Soluble: 0.1-1 mg/ml | [form ]
Oil | [pka]
12.19±0.40(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation[1]. | [Biological Activity]
BAY-390 is an orally activepotent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu19/monkey63/rat68/guinea pig73/mu81/dog; IC50 = 5.6 μM/hTRPC5>25 μM/human TRPV1/4TRPC3/6KCNK9 (TASK-3)CACNA1H (Cav3.2)) th at shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg micep.o.) and neurogenic pain (30 or 90 mg/kg ratsb.i.d. p.o.). | [in vivo]
BAY-390 (30 and 90 mg/kg; p.o.; BID for 10 days) effects the neuropathic pain in vivo[1].
BAY-390 reduces visceral pain in rat cyclophosphamide induced cystitis models[1].
BAY-390 shows efficacy in inflammatory pain and neurogenic inflammation models[1]. | Animal Model: | Nrodent animals with neuropathic pain[1] | | Dosage: | 30 and 90 mg/kg | | Administration: | Oral gavage; 30 and 90 mg/kg; twice daily for 10 days | | Result: | Effectively reduced the neuropathic pain in rodent neuropathic pain model.
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| [References]
[1] |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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