| Identification | Back Directory | [Name]
2-Propenoic acid, 3-[4-(dimethylamino)phenyl]-, 3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl ester | [CAS]
2742707-36-2 | [Synonyms]
AChE-IN-19
2-Propenoic acid, 3-[4-(dimethylamino)phenyl]-, 3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl ester | [Molecular Formula]
C30H33NO7 | [MOL File]
2742707-36-2.mol | [Molecular Weight]
519.59 |
| Hazard Information | Back Directory | [Uses]
AChE-IN-19 (compound A15) is a highly potent AChE inhibitor with an IC50 value of 0.56 μM, also inhibits Aβ aggregation. AChE-IN-19 has potent neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE-IN-19 can be used for researching Alzheimer's disease[1]. | [IC 50]
AChE | [References]
[1] Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917. DOI:10.1016/j.bioorg.2020.103917 |
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