| Identification | Back Directory | [Name]
1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- | [CAS]
2742707-47-5 | [Synonyms]
AChE/BuChE-IN-3
1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C30H30F3N3O6 | [MOL File]
2742707-47-5.mol | [Molecular Weight]
585.57 |
| Hazard Information | Back Directory | [Uses]
AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1]. | [IC 50]
AChE: 0.65 μM (IC50); BChE: 5.77 μM (IC50) | [References]
[1] Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917. DOI:10.1016/j.bioorg.2020.103917 |
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