| Identification | Back Directory | [Name]
HBV-IN-48 | [CAS]
2743466-04-6 | [Synonyms]
HBV-IN-48
1H-Indole-2-carboxamide, N-[(1S)-8,9-difluoro-1,4,5,6-tetrahydro-6-oxo-2H-pyrano[3,4-c]isoquinolin-1-yl]-5,6-difluoro-N-methyl- | [Molecular Formula]
C22H15F4N3O3 | [MOL File]
2743466-04-6.mol | [Molecular Weight]
445.37 |
| Chemical Properties | Back Directory | [Boiling point ]
754.578±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.583±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
10.447±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
HBV-IN-48 is an HBV inhibitor. HBV-IN-48 has antiviral activity against HBV in HepDE19 cells, with an EC50 value of 0.005 μM. HBV-IN-48 can reduce serum HBV DNA levels in mouse models of HBV infection[1]. | [References]
[1] Mesaros E F, et al. Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators[J]. ACS Medicinal Chemistry Letters, 2024. |
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