| Identification | Back Directory | [Name]
3-Piperidinecarboxamide, N-(4,6-difluoro-2-benzothiazolyl)-1-[2-(dimethylamino)ethyl]- | [CAS]
2747162-85-0 | [Synonyms]
MCUF-651
3-Piperidinecarboxamide, N-(4,6-difluoro-2-benzothiazolyl)-1-[2-(dimethylamino)ethyl]- | [Molecular Formula]
C17H22F2N4OS | [MOL File]
2747162-85-0.mol | [Molecular Weight]
368.44 |
| Chemical Properties | Back Directory | [density ]
1.319±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Slightly Soluble: 0.1-1 mg/ml | [form ]
Solid | [pka]
9.60±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1]. | [References]
[1] Sangaralingham SJ, et al. Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118. DOI:10.1073/pnas.2109386118 |
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