| Identification | Back Directory | [Name]
JWH 018 N-pentanoic acid metabolite-d5 | [CAS]
2748533-42-6 | [Synonyms]
JWH 018 N-pentanoic acid metabolite-d5
5-(3-(1-naphthoyl)-1H-indol-1-yl)-pentanoic-2,4,5,6,7-d5-acid | [Molecular Formula]
C24H16D5NO3 | [MOL File]
2748533-42-6.mol | [Molecular Weight]
376.459 |
| Hazard Information | Back Directory | [Description]
JWH 018 N-pentanoic acid metabolite-d5 contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 018 N-pentanoic acid metabolite (Item No. 9000856) by GC- or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-pentanoic acid metabolite is a minor urinary metabolite of JWH 018, characterized by carboxylation of the N-alkyl chain.2 In urine samples, this metabolite is almost completely glucuronidated.2WARNING This product is not for human or veterinary use. | [References]
[1] MIE MIE AUNG . Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding[J]. Drug and alcohol dependence, 2000, 60 2: Pages 133-140. DOI: 10.1016/s0376-8716(99)00152-0
[2] TIM SOBOLEVSKY Grigory R Ilya Prasolov. Detection of JWH-018 metabolites in smoking mixture post-administration urine[J]. Forensic science international, 2010, 200 1: Pages 141-147. DOI: 10.1016/j.forsciint.2010.04.003 |
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