| Identification | Back Directory | [Name]
(2R)-Octyl-α-hydroxyglutarate-d17 | [CAS]
2748638-78-8 | [Synonyms]
(2R)-Octyl-α-hydroxyglutarate-d17
2R-hydroxy-pentanedioicacid,1-octyl-d17ester |
| Hazard Information | Back Directory | [Uses]
(2R)-Octyl-α-hydroxyglutarate-d17 ((2R)-Octyl-2-HG-d17) is deuterium labeled (2S)-Octyl-α-hydroxyglutarate. (2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375). DOI:10.1126/scitranslmed.aal2463 |
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