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Dantrolene-D4 is the deuterium labelled analogue of Dantrolene Sodium Salt Hemiheptahydrate (D185000), which is a (skeletal) muscle relaxant, used in the treatment of malignant hyperthermia. | [References]
[1] MD S K, PHD Masafumi Y M, PHD , et al. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor[J]. Journal of the American College of Cardiology, 2009, 53 21: Pages 1993-2005. DOI: 10.1016/j.jacc.2009.01.065
[2] YE WIN OO. Essential Role of Calmodulin in RyR Inhibition by Dantrolene.[J]. Molecular Pharmacology, 2015, 88 1: 57-63. DOI: 10.1124/mol.115.097691
[3] B A KOTSIAS S M. Reversible effect of dantrolene sodium on twitch tension of rat skeletal muscle.[J]. Archives of neurology, 1978, 35 4: 234-236. DOI: 10.1001/archneur.1978.00500280052010
[4] T E NELSON E H F. Rationale for dantrolene vs. procainamide for treatment of malignant hyperthermia.[J]. Anesthesiology, 1979, 50 2: 118-122. DOI: 10.1097/00000542-197902000-00008 |
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