| Hazard Information | Back Directory | [Description]
Vigabatrin-13C-d2 is intended for use as an internal standard for the quantification of vigabatrin (Item No. 9000976) by GC- or LC-MS. Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor.1 It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice.2 It reduces the incidence of myoclonus in a mouse model of audiogenic seizures.3 Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol (PTZ; Item No. 18682) in mice.4 Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.WARNING This product is not for human or veterinary use. | [References]
[1] BRUCE LIPPERT. 4-Amino-hex-5-enoic Acid, a Selective Catalytic Inhibitor of 4-Aminobutyric-Acid Aminotransferase in Mammalian Brain[J]. The FEBS journal, 1977, 74 3: 441-445. DOI: 10.1111/j.1432-1033.1977.tb11410.x
[2] M. J. JUNG. γ-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE1[J]. Journal of Neurochemistry, 1977, 29 5: 797-802. DOI: 10.1111/j.1471-4159.1977.tb10721.x
[3] BRIAN S. MELDRUM Kamala M. Anticonvulsant action in mice with sound-induced seizures of the optical isomers of γ-vinyl GABA[J]. European journal of pharmacology, 1983, 89 1: Pages 149-152. DOI: 10.1016/0014-2999(83)90620-9
[4] JAROGNIEW J. LUSZCZKI Stanislaw J C. Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2007, 31 2: Pages 529-538. DOI: 10.1016/j.pnpbp.2006.11.020 |
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