| Identification | Back Directory | [Name]
Cinacalcet-d3 (hydrochloride) | [CAS]
2749807-20-1 | [Synonyms]
Cinacalcet-d3 (hydrochloride)
(αR)-α-(methyl-d3)-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine,monohydrochloride | [Molecular Formula]
C22H20ClD3F3N | [MOL File]
2749807-20-1.mol | [Molecular Weight]
396.891 |
| Hazard Information | Back Directory | [Description]
Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet (Item No. 16042) by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).1 In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.2 Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.WARNING This product is not for human or veterinary use. | [References]
[1] JIAN-NONG MA. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 337 1: 275-284. DOI: 10.1124/jpet.110.178194
[2] YASUO IMANISHI. Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism.[J]. Calcified Tissue International, 2011, 89 1: 29-35. DOI: 10.1007/s00223-011-9490-4 |
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