| Hazard Information | Back Directory | [Description]
12-OAHSA-d17 is intended for use as an internal standard for the quantification of 12-OAHSA (Item No. 17108) by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.1 Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-OAHSA is a FAHFA in which oleic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, OAHSAs are the most abundantly expressed in the serum of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.1WARNING This product is not for human or veterinary use. | [References]
[1] MARK M YORE. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.[J]. Cell, 2014, 159 2: 318-332. DOI: 10.1016/j.cell.2014.09.035 |
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