| Identification | Back Directory | [Name]
1,2-Benzisothiazol-3-amine, N-(3,5-dibromophenyl)-, 1,1-dioxide | [CAS]
2750141-15-0 | [Synonyms]
HIF-2α agonist 2
1,2-Benzisothiazol-3-amine, N-(3,5-dibromophenyl)-, 1,1-dioxide | [Molecular Formula]
C13H8Br2N2O2S | [MOL File]
2750141-15-0.mol | [Molecular Weight]
416.09 |
| Chemical Properties | Back Directory | [Boiling point ]
520.3±60.0 °C(Predicted) | [density ]
1.96±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-2.04±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1]. | [References]
[1] Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999. DOI:10.1016/j.ejmech.2020.112999 |
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