| Chemical Properties | Back Directory | [Boiling point ]
740.9±60.0 °C(Predicted) | [density ]
1.387±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.27±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle[1]. | [References]
[1] Rowlands RA, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64(1):566-585. DOI:10.1021/acs.jmedchem.0c01522 |
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